Mahendran, K. R. (2020) Design and Assembly of Transmembrane Helix Barrel. The Journal of membrane biology, 253. pp. 491-497. ISSN 1432-1424

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Abstract

It gives me great pleasure to introduce the following commentary by Dr. Kozhinjampara R. Mahendran, featured as an Up-and-Coming Scientist in the present issue of the Journal of Membrane Biology. Dr. Mahendran holds a Ph.D. in Biochemical Engineering from the Jacobs University Bremen, Germany (Thesis Supervisor: Prof. Mathias Winterhalter) and pursued an initial postdoctoral research stint in a joint collaboration of the Jacobs University Bremen, Germany and the University of Cambridge, UK. Subsequently, he carried out further postdoctoral research in the laboratory of Prof. Hagan Bayley at the University of Oxford, UK, where he demonstrated the fabrication of a novel monodisperse transmembrane α-helical peptide barrel (Mahendran et al. 2017). This breakthrough introduced an exciting dimension to the development of sensors based on membrane proteins, which has been conventionally templated on β-barrel scaffolds. Dr. Mahendran joined the Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India as a DBT-Ramalingaswamy Faculty Fellow in September 2016, where he set up an independent research group working on design principles of sensors and actuators templated on membrane proteins. This commentary offers an overview of emerging paradigms in the field of transmembrane protein sensors, with an emphasis on the challenges and excitements inherent in the adaptation of α-helical transmembrane proteins and peptides to these applications. Work from his group (Satheesan and Mahendran 2018; Krishnan et al. 2019; Puthumadathil et al. 2019; Vikraman et al. 2020) has established designer α-helical peptide barrels as powerful models for unraveling the grammar of membrane protein folding and viable alternatives for engineering single-molecule sensors and peptide-based therapeutics.

Item Type:	Article
Subjects:	Genomics Facility
Depositing User:	Central Library RGCB
Date Deposited:	27 Jan 2021 10:27
Last Modified:	27 Jan 2021 10:27
URI:	http://rgcb.sciencecentral.in/id/eprint/1015

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