[feed] Atom [feed] RSS 1.0 [feed] RSS 2.0

Sabira, Mohammed and Aparna , Jayasekharan S and Manendra Babu , Lankadasari and Harikumar, Kuzhuvelil B (2020) Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity. FASEB journal, 34 (3). pp. 4329-4347. ISSN 1530-6860

[img] Text
Regulatory role of SphK1(HHS Public).pdf
Restricted to Registered users only

Download (2713Kb) | Request a copy


Plasmacytoid dendritic cells (pDCs) express Toll like receptors (TLRs) that modulate the immune response by production of type I interferons. Here, we report that sphingosine kinase 1 (SphK1) which produces the bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P), plays a critical role in the pDC functions and interferon production. Although dispensable for the pDC development, SphK1 is essential for the pDC activation and production of type I IFN and pro-inflammatory cytokines stimulated by TLR7/9 ligands. SphK1 interacts with TLRs and specific inhibition or deletion of SphK1 in pDCs mitigates uptake of CpG oligonucleotide ligands by TLR9 ligand. In the pristane-induced murine lupus model, pharmacological inhibition of SphK1

Item Type: Article
Uncontrolled Keywords: auto-immunity; interferon; plasmacytoid dendritic cells; sphingosine 1-Phosphate; sphingosine kinase; systemic lupus erythematosus.
Subjects: Cancer Research
Depositing User: Central Library RGCB
Date Deposited: 17 Mar 2021 06:54
Last Modified: 17 Mar 2021 06:54
URI: http://rgcb.sciencecentral.in/id/eprint/1020

Actions (login required)

View Item View Item