Archana P, Thankamony and Radhika, Nair (2021) Lineage Plasticity in Cancer: The Tale of a Skin-Walker. Cancers, 13 (14). ISSN 2072-6694

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Abstract

Lineage plasticity, the switching of cells from one lineage to another, has been recognized as a cardinal property essential for embryonic development, tissue repair and homeostasis. However, such a highly regulated process goes awry when cancer cells exploit this inherent ability to their advantage, resulting in tumorigenesis, relapse, metastasis and therapy resistance. In this review, we summarize our current understanding on the role of lineage plasticity in tumor progression and therapeutic resistance in multiple cancers. Lineage plasticity can be triggered by treatment itself and is reported across various solid as well as liquid tumors. Here, we focus on the importance of lineage switching in tumor progression and therapeutic resistance of solid tumors such as the prostate, lung, hepatocellular and colorectal carcinoma and the myeloid and lymphoid lineage switch observed in leukemias. Besides this, we also discuss the role of epithelial-mesenchymal transition (EMT) in facilitating the lineage switch in biphasic cancers such as aggressive carcinosarcomas. We also discuss the mechanisms involved, current therapeutic approaches and challenges that lie ahead in taming the scourge of lineage plasticity in cancer.

Item Type:	Article
Uncontrolled Keywords:	lineage plasticity, tumor progression, metastasis, therapy resistance, epithelial-mesenchymal plasticity
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	30 Sep 2021 06:51
Last Modified:	30 Sep 2021 06:51
URI:	http://rgcb.sciencecentral.in/id/eprint/1044

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