Shirley, James and Jayasekharan, S Aparna and Anu, Babu and Aswathy, Mary Paul and Manendra, Babu Lankadasari and Subha, R Athira and Sreesha , S Kumar and Yadu, Vijayan and Narayanan , N Namitha and Sabira , Mohammed and Reshmi , Girijadevi and Harikumar , K B (2021) Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer. Biomolecules, 11 (5). ISSN 2218-273X

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Abstract

Cardamonin is a naturally occurring chalcone, majorly from the Zingiberaceae family, which includes a wide range of spices from India. Herein, we investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems. In RAW 264.7 cells, treatment with cardamonin showed a reduced nitrous oxide production without affecting the cell viability and decreased the expression of iNOS, TNF-α, and IL-6, and inhibited NF-kB signaling which emphasizes the role of cardamonin as an anti-inflammatory molecule. In a mouse model of dextran sodium sulfate (DSS)-induced colitis, cardamonin treatment protected the mice from colitis. Subsequently, we evaluated the therapeutic potential of this chalcone in a colitis-associated colon cancer model. We performed microRNA profiling in the different groups and observed that cardamonin modulates miRNA expression, thereby inhibiting tumor formation. Together, our findings indicate that cardamonin has the potential to be considered for future therapy against colorectal cancer.

Item Type:	Article
Uncontrolled Keywords:	azoxymethane; cardamonin; colitis; colorectal cancer; microRNA; nutraceutical.
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	07 Jan 2022 07:02
Last Modified:	07 Jan 2022 07:02
URI:	http://rgcb.sciencecentral.in/id/eprint/1073

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