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Karthika, Chandran Latha and Ahalya, Sreekumar and Vyshna , Beena (2021) Shear Stress Alterations Activate BMP4/pSMAD5 Signaling and Induce Endothelial Mesenchymal Transition in Varicose Veins. Cells, 10 (12). ISSN 2073-4409

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Chronic venous diseases, including varicose veins, are characterized by hemodynamic disturbances due to valve defects, venous insufficiency, and orthostatism. Veins are physiologically low shear stress systems, and how altered hemodynamics drives focal endothelial dysfunction and causes venous remodeling is unknown. Here we demonstrate the occurrence of endothelial to exposed to disturbed flow. We conclude that disturbed shear stress, even in the absence of any oscillatory flow, induces EndMT in varicose veins via activation of BMP4/pSMAD5-SNAI1/2 signaling. The present findings serve as a rationale for the possible use of small molecular mechanotherapeutics in the management of varicose veins.

Item Type: Article
Uncontrolled Keywords: BMP; EndMT; TGFβ; endothelial cells; shear stress; varicose veins.
Subjects: Cardiovascular Diseases And Diabetes Biology
Depositing User: Rgcb Library
Date Deposited: 22 Feb 2022 07:54
Last Modified: 22 Feb 2022 07:54
URI: http://rgcb.sciencecentral.in/id/eprint/1124

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