Juberiya M, Azeez and Susmi , T R and Viji, Remadevi and Vini , Ravindran and Anjana , Sasikumar Sujatha and Sobha Ayswarya , Raveendran Nair and Sreeja , S. (2021) New insights into the functions of progesterone receptor (PR) isoforms and progesterone signaling. American journal of cancer research, 11 (11). pp. 5214-5232. ISSN 2156-6976

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Abstract

Progesterone, the ovarian steroid hormone, regulates a plentitude of biological processes in tissues ranging from the brain to bones. Recognizing the role of progesterone and its receptors in physiological processes and maladies can prevent and treat various diseases. Apart from its physiological functions, its role in developing diseases, especially breast cancer, is a recent topic of deliberation. There exists conflicting experimental and epidemiological evidence linking progesterone to breast cancer. This review tries to describe the physiological functions of progesterone and its receptors, genomic and non-genomic signaling, splice variants, and a different aspect of progesterone signaling. Furthermore, we seek to address or attempt to discuss the following pertinent questions on steroid hormone signaling; How does progesterone influence breast cancer progression? How does it change the molecular pathways in breast cancer with different receptor statuses, the specific role of each isoform, and how does the ER/and PR ratio affect progesterone signaling?

Item Type:	Article
Uncontrolled Keywords:	Progesterone; cancer; physiological functions; progesterone receptor.
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	25 Feb 2022 07:24
Last Modified:	25 Feb 2022 07:24
URI:	http://rgcb.sciencecentral.in/id/eprint/1131

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