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N., Ashwanikumar and Nisha, Asok Kumar and S. Asha , Nair and G.S., Vinod Kumar (2014) 5-Fluorouracil–lipid conjugate: Potential candidate for drug delivery through encapsulation in hydrophobic polyester-based nanoparticles. Acta biomaterialia, 10 (11). pp. 4685-4694. ISSN 1878-7568

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Abstract

The encapsulation of 5-fluorouracil (5-FU) in hydrophobic polymeric materials is made feasible by a lipid-based prodrug approach. A lipid-5-FU conjugate of 5-FU with palmitic acid was synthesized in two-step process. A synthesized dipalmitoyl derivative (5-FUDIPAL) was characterized using Fourier transform infrared spectroscopy and (1)H-nuclear magnetic resonance. The 5-FUDIPAL was encapsulated in polyester-based polymers by the double emulsion-solvent evaporation method. The nanoparticles were characterized by scanning electron microscopy, transmission electron microscopy and dynamic light scattering. The thermal stability was assessed by differential scanning calorimetry data. In vitro release kinetics measurements of the drug from nanoparticles showed the controlled release pattern over a period of time. Cytotoxicity measurements by MTT assay confirmed that dipalmitoyl derivative in nano formulation successfully inhibited the cell growth. Thus the combined physical and biological evaluation of the different polyester-based nanoparticle containing the modified drug showed a facile approach to delivering 5-FU to the tumour site with enhanced efficacy.

Item Type: Article
Uncontrolled Keywords: Polyester; 5-Fluorouracil; Palmitic acid; Nanoparticles
Subjects: Cancer Research
Chemical Biology
Depositing User: Rgcb Library
Date Deposited: 17 Jan 2017 07:39
Last Modified: 17 Jan 2017 07:39
URI: http://rgcb.sciencecentral.in/id/eprint/166

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