Hezlin, Marzook and S., Deivendran and Rakesh, Kumar and M R, Pillai (2014) Role of MTA1 in head and neck cancers. Cancer metastasis reviews, 33 (4). pp. 953-964. ISSN 1573-7233

Text Role of MTAI (Cancer Metastasis Rev).pdf Restricted to Registered users only Download (2079Kb) | Request a copy

Abstract

Head and neck cancers usually originate in the squamous cells that line the inner mucosal surfaces of the oral and the neck region. These cancers follow multifocal steps for progression that include risk of developing metastasis. Although therapeutics has advanced in the past decades, head and neck cancers continue to cause much morbidity and mortality. Even with the promising effect of targeted therapies, there is a need for a better evaluation of patients with head and neck cancers. Metastasis-associated tumour antigen 1 (MTA1), a chromatin modifier, is found as an integral part of nucleosome remodelling and histone deacetylation (NuRD) complex. MTA1 is a biomarker for several solid tumours, and the overexpression of which have been documented in various cancers such as breast, ovarian, colon, prostrate etc. Interestingly also, a set of head and neck cancers shows MTA1 overexpression. However, recent evidences from clinical data raise a critical question on the role of MTA1 in head and neck cancers. This calls for a detailed review to the role of MTA1 in oral cancer. This review gives a brief account on the existing biological and molecular data in the context of head and neck cancer invasion and metastasis in relation to MTA1.

Item Type:	Article
Uncontrolled Keywords:	Head and neck squamous cell carcinoma (HNSCC)Human papillomavirus (HPV)Metastasis tumour antigen 1 (MTA1)Nasopharyngeal cancer (NPC)InvasionMetastasis
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	19 Jan 2017 04:14
Last Modified:	19 Jan 2017 04:14
URI:	http://rgcb.sciencecentral.in/id/eprint/172

Actions (login required)

View Item