Biljo V. , Joseph and Smitha, Soman and R. Ajay , Kumar and Sathish , Mundayoor (2013) Efficient discrimination by MIRU-VNTRs of Mycobacterium tuberculosis clinical isolates belonging to the predominant SIT11/EAI3-IND ancestral genotypic lineage in Kerala, India. International journal of mycobacteriology, 2 (4). pp. 244-247. ISSN 2212-554X

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Abstract

The present study evaluated the ability of MIRU-VNTRs to discriminate Mycobacterium tuberculosis (MTB) clinical isolates belonging to the SIT11/EAI3-IND ancestral genotypic lineage, which is highly prevalent in Kerala, India. Starting from 168 MTB clinical isolates, spoligotyping (discriminatory index of 0.9113) differentiated the strains into 68 distinct patterns, the biggest cluster being SIT11/48 SIT11 (n=48). The present study shows that 12-loci MIRUs and 3 ETRs allowed an efficient discrimination of these isolates (discriminatory indexes of 0.7819 and 0.5523, respectively).

Item Type:	Article
Uncontrolled Keywords:	Mycobacterium tuberculosis; Kerala; India; IS6110-RFLP; MIRU-VNTR; Spoligotyping
Subjects:	Mycobacterium Research
Depositing User:	Central Library RGCB
Date Deposited:	25 Jan 2017 03:59
Last Modified:	25 Jan 2017 03:59
URI:	http://rgcb.sciencecentral.in/id/eprint/190

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