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Vinitha , Richard and Madhumathy , G. Nair and Sree Narayanan, Nair and Tessy Thomas, Maliecka and T.R., Santhosh Kumar and M. R, Pillai (2013) Multiple drug resistant, tumorigenic stem-like cells in oral cancer. Cancer letters, 338 (2). pp. 300-316. ISSN 1872-7980

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An in vitro cell line model was established to exemplify tumor stem cell concept in oral cancer. We were able to identify CD147 expressing fractions in SCC172 OSCC cell line with differing Hoechst dye efflux activity and DNA content. In vivo tumorigenic assay revealed three fractions enriched with stem-like cells capable of undergoing mesenchymal transition and a non-tumorigenic fraction. The regeneration potential and transition of one fraction to other imitated the phenotypic switch and functional disparities evidenced during oral tumor progression. Knowledge of these additional stem-like subsets will improve understanding of stem cell based oral epithelial tumor progression from normal to malignant lesions.

Item Type: Article
Uncontrolled Keywords: Oral cancer; Minimal residual disease; Cancer stem cells; Side population; Multi-drug resistance; Tumorigenic potential
Subjects: Cancer Research
Depositing User: Rgcb Library
Date Deposited: 01 Feb 2017 04:41
Last Modified: 01 Feb 2017 04:41
URI: http://rgcb.sciencecentral.in/id/eprint/195

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