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Divya, M.S. and Rasheed, V.A. and Jackson , James (2013) Neuronal differentiation of embryonic stem cell derived neuronal progenitors can be regulated by stretchable conducting polymers. Tissue engineering. Part A, 19 (17-18). pp. 1984-1993. ISSN 1937-335X

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Abstract

Electrically conducting polymers are prospective candidates as active substrates for the development of neuroprosthetic devices. The utility of these substrates for promoting differentiation of embryonic stem cells paves viable routes for regenerative medicine. Here, we have tuned the electrical and mechanical cues provided to the embryonic stem cells during differentiation by precisely straining the conducting polymer (CP) coated, elastomeric-substrate. Upon straining the substrates, the neural differentiation pattern occurs in form of aggregates, accompanied by a gradient where substrate interface reveals a higher degree of differentiation. The CP domains align under linear stress along with the formation of local defect patterns leading to disruption of actin cytoskeleton of cells, and can provide a mechano-transductive basis for the observed changes in the differentiation. Our results demonstrate that along with biochemical and mechanical cues, conductivity of the polymer plays a major role in cellular differentiation thereby providing another control feature to modulate the differentiation and proliferation of stem cells.

Item Type: Article
Subjects: Neuro Stem Cell Biology
Depositing User: Rgcb Library
Date Deposited: 01 Feb 2017 05:11
Last Modified: 12 Apr 2019 07:48
URI: http://rgcb.sciencecentral.in/id/eprint/196

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