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Kunnambath, R. and Pillai, R.M. (2013) Management of Radiation-Induced Oral Mucositis With an Herbal Mouthwash. International Journal of Radiation Oncology*Biology*Physics, 87 (2). S143-S144.

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To find the effectiveness of ayurvedic herbal mouthwash containing five herbal ingredients in reducing severity of oral mucositis which is the major dose limiting toxicity in patients undergoing radical radiation therapy for oral cancers. Materials/Methods: This study was carried out at a single institution. Between December 2004 and February 2006, 148 patients with biopsy proven squamous cell carcinoma of oral cavity, intended to be treated with radiation were randomized using a computer generated randomization chart, 75 to the intervention arm and 73 to the control arm. This study was approved by Institute Human Ethics Committee. Informed consents were obtained from all patients. Patients in intervention arm were advised to rinse mouth with herbal mouthwash 4 times daily and those in control arm were advised soda saline mouthwash during the entire period of radiation therapy. All patients received external beam radiation therapy 5 days a week up to a total dose of 5250 c Gy in 15 fractions over 3 weeks period. All these patients were evaluated weekly by a single physician, who was blinded to randomization procedure (blinded assessor). RTOG grading of mucositis was used to assess the grade of mucositis. Pain intensity was scored on a 10-point scale using a Visual Analogous Scale (VAS). Anal- gesics use among these patients was assessed on the basis of WHO step ladder analgesic requirement. The response to treatment was assessed at 5- 6 months after completion of radiation therapy. Results: Base line characteristics of patients in both arms were compa- rable. Number of patients received chemotherapy was higher in inter- vention arm. The intensity of pain at the end of radiation therapy was less in intervention arm. Severe pain (7-10 score on VAS) was experienced by 5.4% patients in intervention arm compared to 45.7% in control arm ( p < 0.001). Onset of mucositis was significantly delayed in patients in intervention arm. The analgesic requirement was low in intervention arm.

Item Type: Article
Subjects: Cancer Research
Depositing User: Rgcb Library
Date Deposited: 02 Feb 2017 08:46
Last Modified: 12 Apr 2019 07:51
URI: http://rgcb.sciencecentral.in/id/eprint/205

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