Suresh B. , Pakala and M R, Pillai and Rakesh, Kumar (2013) MTA1 Promotes STAT3 Transcription and Pulmonary Metastasis in Breast Cancer. Cancer research, 73 (12). 3761-3770. . ISSN 1538-7445

Text MTA1 Promotes STAT3.pdf Restricted to Registered users only Download (3409Kb)

Abstract

Overexpression of the prometastatic chromatin modifier protein metastasis tumor antigen 1 (MTA1) in human cancer contributes to tumor aggressiveness, but the role of endogenous MTA1 in cancer has not been explored. Here, we report the effects of selective genetic depletion of MTA1 in a physiologically relevant spontaneous mouse model of breast cancer pulmonary metastasis. We found that MTA1 acts as a mandatory modifier of breast-to-lung metastasis without effects on primary tumor formation. The underlying mechanism involved MTA1-dependent stimulation of STAT3 transcription through action on the MTA1/STAT3/Pol II coactivator complex, and, in turn, on the expression and functions of STAT3 target genes including Twist1. Accordingly, we documented a positive correlation between levels of MTA1 and STAT3 in publicly available breast cancer data sets. Together, our findings reveal an essential modifying role of the physiologic level of MTA1 in supporting pulmonary metastasis of breast cancer.

Item Type:	Article
Uncontrolled Keywords:	MTA1, Coactivator, STAT3 Transcription, Metastasis
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	07 Feb 2017 06:21
Last Modified:	07 Feb 2017 06:21
URI:	http://rgcb.sciencecentral.in/id/eprint/216

Actions (login required)

View Item