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Balan , S and Vellichirammal, NN and Moinak , Banerjee (2012) Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis. Epilepsy research, 101 (3). pp. 288-292. ISSN 1872-6844

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We compared the allele and genotype frequencies of SCN1A SNP rs3812718 between patients with MTLE-HS of south Indian ancestry with and without febrile seizures (FS) and with ethnically matched controls. While we observed no significant difference in allele and genotype frequencies of rs3812718 between MTLE-HS patients with and without FS, A allele and AA genotype were overrepresented in MTLE-HS patients when compared to controls. We conclude that in the population studied, although rs3812718 polymorphism increases the susceptibility to MTLE-HS, this is not by increasing the susceptibility to FS.

Item Type: Article
Uncontrolled Keywords: Febrile seizures; Genetic association; Hippocampal sclerosis; Mesial temporal lobe epilepsy; SCN1A polymorphisms
Subjects: Human Molecular Genetics
Depositing User: Rgcb Library
Date Deposited: 01 Mar 2017 03:19
Last Modified: 01 Mar 2017 03:19
URI: http://rgcb.sciencecentral.in/id/eprint/272

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