Murty, M. S. R. and Lekshmi , Nath R. and Ruby John, Anto (2013) Synthesis of piperazinyl benzothiazole/benzoxazole derivatives coupled with 1,3,4-oxadiazole-2-thiol: novel hybrid heterocycles as anticancer agents. Medicinal Chemistry Research, 22 (10). pp. 4980-4991. ISSN 1554-8120

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Abstract

The synthesis of a series of substituted 2-(piperazin-1-yl)benzothiazole/benzoxazole coupled with 1,3,4-oxadiazole-2-thiol pharmacophore (8a–t) is described using a three carbon spacer (Jones and Helm, Drugs 69:1903–1910, 2009). The structures of the compounds were confirmed by NMR and mass spectral data. All the synthesized compounds have been evaluated for their cytotoxicity towards five human cancer cell lines of different origins, viz. MCF-7 (Breast), HeLa (Cervical), HepG2 (Liver), A431 (Skin) and A549 (Lung), and IC50 values were determined. Among the compounds tested, 8j and 8t displayed maximum cytotoxic activity. A431 was the most sensitive cell line against the compounds studied, followed by MCF7, A549, HepG2 and HeLa.

Item Type:	Article
Uncontrolled Keywords:	PiperazineBenzothiazoleBenzoxazole1,3,4-OxadiazoleAnticancerMTT assay
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	02 Mar 2017 07:48
Last Modified:	12 Apr 2019 07:47
URI:	http://rgcb.sciencecentral.in/id/eprint/283

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