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Rengaswamy, Sankaranarayanan and Priya, R Prabhu and Janki Mohan Babu , Vijayamma and Subha , Sankaran and Thiraviam Pillai Rameshwari Ammal , Kannan and Rintu , Varghese and M R, Pillai (2016) Immunogenicity and HPV infection after one, two, and three doses of quadrivalent HPV vaccine in girls in India: a multicentre prospective cohort study. The Lancet Oncology, 17 (1). p67- 77.

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Abstract

An increase in worldwide HPV vaccination could be facilitated if fewer than three doses of vaccine are as effective as three doses. We originally aimed to compare the immunogenicity and frequency of persistent infection and cervical precancerous lesions caused by vaccine-targeted HPV after vaccination with two doses of quadrivalent vaccine on days 1 and 180 or later, with three doses on days 1, 60, and 180 or later, in a cluster-randomised trial. Suspension of the recruitment and vaccination due to events unrelated to our study meant that some enrolled girls could not be vaccinated and some vaccinated girls received fewer than the planned number of vaccinations by default. As a result, we re-analysed our data as an observational cohort study.

Item Type: Article
Subjects: Cancer Research
Depositing User: Rgcb Library
Date Deposited: 24 Mar 2017 07:03
Last Modified: 07 Nov 2018 07:26
URI: http://rgcb.sciencecentral.in/id/eprint/320

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