SEBASTIAN , JOHN and RASHMI , MISHRA (2016) Galectin-9: From cell biology to complex disease dynamics. Journal of biosciences, 41 (3). pp. 507-34. ISSN 0973-7138

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Abstract

Galectins is a family of non-classically secreted, beta-galactoside-binding proteins that has recently received considerable attention in the spatio-temporal regulation of surface 'signal lattice' organization, membrane dynamics, cell-adhesion and disease therapeutics. Galectin-9 is a unique member of this family, with two non-homologous carbohydrate recognition domains joined by a linker peptide sequence of variable lengths, generating isoforms with distinct properties and functions in both physiological and pathological settings, such as during development, immune reaction, neoplastic transformations and metastasis. In this review, we summarize the latest knowledge on the structure, receptors, cellular targets, trafficking pathways and functional properties of galectin-9 and discuss how galectin-9-mediated signalling cascades can be exploited in cancers and immunotherapies.

Item Type:	Article
Uncontrolled Keywords:	Cancer; carbohydrate recognition domain; galectin-9; immune-regulation; linker peptide
Subjects:	Disease Biology
Depositing User:	Central Library RGCB
Date Deposited:	29 Mar 2017 07:23
Last Modified:	29 Mar 2017 07:23
URI:	http://rgcb.sciencecentral.in/id/eprint/333

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