Reshmi, G. and Surya, Ramachandran and V.T., Jissa and P.S., Saneesh Babu and N.R., Preethi and W.S., Santhi and Pillai, M. R (2011) C–T variant in a miRNA target site of BCL2 is associated with increased risk of human papilloma virus related cervical cancer—An in silico approach. Genomics, 98 (3). pp. 189-193. ISSN 1089-8646

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Abstract

MicroRNAs control gene expression at the posttranscriptional level by base-pairing to the 3'-UTR of their target mRNAs, thus leading to mRNA degradation of protein fabrication. We hypothesize, SNPs within miRNAs and their targets could be of significance to an individual's risk of developing cancer. We analyzed in silico SNP information on cervical cancer associated aberrant alleles and further investigated this in a case-control study by examining eleven SNPs from different genes. It was observed that a C to T polymorphism in putative miRNA target site of BCL2 was significantly conspicuous for the aberrant SNP allele in cancer tissues as compared to controls. This study provides evidence that SNPs in miRNA-binding sites may play an important role in increasing risk of cancer. The results also paves way for future studies to validate these results in other well-characterized populations as well as to explore the biological significance of these particular SNPs.

Item Type:	Article
Uncontrolled Keywords:	MicroRNAs; Single-nucleotide polymorphism; Un-translated region; Human Papilloma Virus (HPV); Cervical Intraepithelial Neoplasia (CIN); B-cell CLL/lymphoma 2 (BCL2)
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	26 Apr 2017 06:13
Last Modified:	26 Apr 2017 06:13
URI:	http://rgcb.sciencecentral.in/id/eprint/351

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