Janki Mohan, Babu and R., Prathibha and V.S., Jijith and Ramkumar , Hariharan and Pillai, M. R (2011) A miR-centric view of head and neck cancers. Biochimica et biophysica acta, 1816 (1). pp. 67-72. ISSN 1878-2434

Text A miR-Centric (Biochimica et Biophysics Acta-Reviews on Cancer).pdf Restricted to Registered users only Download (281Kb)

Abstract

Head and Neck Squamous Cell Carcinomas (HNSCCs) constitute the sixth most common cancer worldwide with an average 5-year survival rate of around 50%. Several microRNAs, small non-coding RNAs involved in post-transcriptional gene regulation, have been linked to HNSCC based on their differential expression in tumors. Here, we present a compilation of multiple types of information on each HNSCC linked miRNA including their expression status in tumors, their molecular targets relevant to cancer, results of gene manipulation studies and association with clinical outcome. Further, we use this information to devise a new scheme for classifying them into causal and non-causal miRNAs in HNSCC. We also discuss the possibility of using miRNAs as prognostic and diagnostic biomarkers for HNSCC, based on existing literature. Finally, we present available evidence that shows how altered expression of specific miRNAs can contribute to various “hallmarks of cancer” phenotypes such as limitless replicative potential owing to abnormal cell cycle regulation, evasion of apoptosis, reduced response to anti-growth signals, and Epithelial–Mesechymal transition (EMT).

Item Type:	Article
Uncontrolled Keywords:	Head and neck squamous cell carcinoma; MicroRNA; Biomarker; Oral cancer
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	02 May 2017 06:06
Last Modified:	02 May 2017 06:06
URI:	http://rgcb.sciencecentral.in/id/eprint/364

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