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Murty, M. S. R. and Ramalingeswara Rao, B. and Kesur R. , Ram and Yadav, J. S. and Jayesh , Antony and Ruby John , Anto (2012) Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted- piperazine-1-yl)propyl]pyridazin-3( 2H )-one derivatives as anticancer agents. Medicinal Chemistry Research, 21 (10). pp. 3161-3169. ISSN 1554-8120

synthesis and preliminary evaluation Medicinal Chem Res.pdf

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A series of new 4-(aryl/heteroaryl-2-ylmethyl)- 6-phenyl-2-[3-(4-substituted piperazine-1-yl)propyl] pyri- dazin-3( 2H )-one derivatives were synthesized. The struc- tures of the compounds were confirmed by IR, 1 HNMR, and mass spectral data. All the compounds were evaluated for their cytotoxicity toward five human cancer cell lines of different origins viz; HeLa (Cervical), SKBR3 (Breast), HCT116 (Colon), A375 (Skin) & H1299 (Lung) at differ- ent concentrations and the IC 50 values were determined. HCT116 and HeLa are the most sensitive against the compounds studied. One of them displayed moderate cytotoxicity against SKBR3. Majority of the compounds exhibited good to moderate activity.

Item Type: Article
Uncontrolled Keywords: Pyridazinones Cyclic amines Hydrazide Anticancer activity
Subjects: Cancer Research
Depositing User: Rgcb Library
Date Deposited: 01 Jun 2017 08:11
Last Modified: 04 Jul 2019 07:57
URI: http://rgcb.sciencecentral.in/id/eprint/366

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