Veena , Somasundaram and Priya, Srinivas (2012) Insights IntotheTargeted Elimination of BRCA1-Defective Cancer Stem Cells. Medicinal research reviews, 32 (5). pp. 948-967. ISSN 1098-1128

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Abstract

BRCA1 expression is involved in normal embryonic development, mammary stem cell differentiation, and prostate cancer development. Inactivation of BRCA1 plays an important role in cancer stem cells and also leads to the development of high-grade, basal-like tumor. This review discusses why BRCA1-defective cancer stem cells need a prospective analysis, how ER alpha could influence BRCA1-defective tumor progression, phenotype of BRCA1-defective cancers, role of BRCA1 in other cancers and finally at what perspective BRCA1-defective cancers can be targeted for better therapeutic outcome.

Item Type:	Article
Uncontrolled Keywords:	BRCA1; cancer stem cells; targeted therapy
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	09 Jun 2017 05:29
Last Modified:	14 Aug 2018 07:15
URI:	http://rgcb.sciencecentral.in/id/eprint/373

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