Priya , Suboj and Priya , Srinivas (2012) Aloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human Colon Cancer Cells. Pharmacology, 89 (1-2). ISSN 1423-0313

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Abstract

Aloe emodin (AE), a natural anthraquinone, is reported to have antiproliferative activity in various cancer cell lines. In this study, we analyzed the molecular mechanisms involved in the growth-inhibitory activity of this hydroxyanthraquinone in colon cancer cell, WiDr. In our observation AE inhibited cell proliferation by arresting the cell cycle at the G2/M phase and inhibiting cyclin B1. AE appreciably induced cell death specifically through the induction of apoptosis and by activating caspases 9/6. Apoptotic execution was found to be solely dependent on caspase-6 rather than caspase-3 or caspase-7. This is the first study indicating that the AE induces apoptosis specifically through the activation of caspase-6.

Item Type:	Article
Uncontrolled Keywords:	Aloe emodin � Caspase � Apoptosis � Colon cancer
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	12 Jun 2017 07:09
Last Modified:	12 Jun 2017 07:09
URI:	http://rgcb.sciencecentral.in/id/eprint/379

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