Santhosh Kumar , Sankaran and Ajith Kumar , G.S and Binil Raj , S.S and Rajagopal., R (2014) Two different rat models for cardiac hypertrophy by constriction of ascending and abdominal aorta. journal of Laboratory Animal Science, 2 (1).

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Abstract

Atherosclerosis is one of the important life style diseases of human beings. There are several animal models in vogue for studying the patho-physiology of Atherosclerosis. It is usually done by inducing pressure overload of aorta. In this study we attempted two different murine models by constriction of thoracic aorta (ascending aorta) and by constriction of abdominal aorta, using metal clips. It was observed that thoracic aorta banding requires expertise, expensive equipment and an increased mortality rate compared to abdominal aorta banding. But the time period for the development of cardiac hypertrophy was lesser in thoracic method (2-4 months) compared to abdominal aorta approach (20-24 months).

Item Type:	Article
Uncontrolled Keywords:	Atherosclerosis, cardiac hypertrophy, rats, aorta
Subjects:	Cardiovascular Diseases And Diabetes Biology
Depositing User:	Central Library RGCB
Date Deposited:	06 Jul 2017 10:04
Last Modified:	06 Jul 2017 10:04
URI:	http://rgcb.sciencecentral.in/id/eprint/393

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