Shammy , S and C C, Kartha (2014) Congenital Heart Defects - Progress and Prospects. Cardiological Society of India (CSI)-Kerala , 4 (2). ISSN 2454-6755

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Abstract

Congenital heart defects (CHD) are a leading cause of mortality in infants. Management of patients with congenital heart diseases has been greatly transformed during the past six decades; nevertheless the underlying causes for the defects and pathogenic mechanisms remain enigmatic. Tools of molecular biology and human genetics have provided avenues for recognizing disease genes causing congenital heart defects. A small portion of all cases of congenital heart defects can be attributed to Mendelian inheritance, chromosomal anomalies or the action of known environmental teratogenic agents. There is seldom any evidence of the causative agents in the common forms of CHD. A better understanding of the molecular and genetic mechanisms of heart development is expected to help in delineating the morphogenesis of cardiac anomalies and in defining ways of effective prevention or in utero repair of the defects at embryonic or fetal stage.

Item Type:	Article
Subjects:	Cardiovascular Diseases And Diabetes Biology
Depositing User:	Central Library RGCB
Date Deposited:	10 Jul 2017 06:44
Last Modified:	10 Jul 2017 06:44
URI:	http://rgcb.sciencecentral.in/id/eprint/397

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