Jaggaiah N., Gorantla and Lekshmi R., Nath and Ruby John , Anto (2014) Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of ‘suicide tree’ Cerbera odollam. Natural product research, 28 (18). 1507-1512. ISSN 1478-6427

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Abstract

We report the isolation of two known iridoid glucosides theviridoside (1) and theveside (2) from the aqueous extract of leaves of Cerbera odollam and semi-synthetic derivatisation of theveside prepared in a single step under protection group-free conditions. Derivatives 2a-j were evaluated for cytotoxicity towards five human cancer cell lines of different origins, namely SKBR3 (breast), HeLa (cervical), A375 (skin), HepG2 (liver) and HCT-116 (colon), and IC50 values were determined. Derivatives 2b and 2h exhibited moderate cytotoxicity against HCT-116 and A375 cell lines, respectively.

Item Type:	Article
Uncontrolled Keywords:	Cerbera odollam; theviridoside; theveside; semi-synthetic derivatives; cytotoxicity
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	13 Jul 2017 06:44
Last Modified:	13 Jul 2017 06:44
URI:	http://rgcb.sciencecentral.in/id/eprint/401

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