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Surya , Ramachandran and C.C. , Kartha (2012) Cyclophilin-A: a potential screening marker for vascular disease in type-2 diabetes. Canadian journal of physiology and pharmacology, 90 (8). pp. 1005-15. ISSN 1205-7541

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Abstract

The pathophysiology of vascular disease in diabetes involves abnormalities in endothelial cells, vascular smooth muscle cells, and monocytes. The metabolic abnormalities that characterize diabetes, such as hyperglycemia, increased free fatty acids, and insulin resistance, each provoke molecular mechanisms that contribute to vascular dysfunction. Several molecules have been identified as risk markers, and have been studied to prevent progression of disease and long-term complications. Markers such as C-reactive protein and monocyte chemoattractant protein-1 are used to assess risk for adverse cardiac events, but elevated levels are possible due to the presence of other risk factors as part of the natural physiological defense mechanism. In this review we discuss potential of cyclophilin-A, a secreted oxidative-stress-induced immunophilin with diverse functions. We present evidence for a significant role of cyclophilin-A in the pathogenesis of atherosclerosis in diabetes, and its potential as a marker for vascular disease in type-2 diabetes.

Item Type: Article
Uncontrolled Keywords: inflammation, vascular disease, type-2 diabetes, cyclophilin-A, monocytes
Subjects: Cardiovascular Diseases And Diabetes Biology
Depositing User: Rgcb Library
Date Deposited: 19 Jul 2017 06:55
Last Modified: 19 Jul 2017 06:55
URI: http://rgcb.sciencecentral.in/id/eprint/411

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