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Soumya, V and Renjini A., Padmanabhan and Shiny, Titus and Malini, Laloraya (2016) Murine uterine decidualization is a novel function of autoimmune regulator-beyond immune tolerance. American journal of reproductive immunology, 76 (3). pp. 224-34. ISSN 1600-0897

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PROBLEM: Autoimmune polyendocrinopathy, candidiasis, and ectodermal dystrophy (APECED, APS-1) patients characterized by Aire (autoimmune regulator) mutations and Aire homozygous knockouts (Aire(-/-) ) exhibit infertility. It is not clear as to what contributes to infertility in the above. METHOD OF STUDY: This study investigates the expression of "AIRE in the uterus" and its contribution to early pregnancy of mice by using quantitative real-time PCR analysis, immunohistochemistry, Western blotting, and in vivo Aire silencing experiments. RESULTS: Aire (Isoform 1a) is expressed in the uterus during the "window of implantation" and decidualization. In vivo Aire silencing interfered with formation of implantation sites and stromal cell transformation by regulating bone morphogenetic protein-2,4 (Bmp2, Bmp4), homeobox A10 (Hoxa10), and insulin-like growth factor-binding protein 1(Igfbp1) leading to pregnancy failure. CONCLUSION: Our consolidated results on extrathymic uterine expression of AIRE during early pregnancy and decidualization and impaired fertility on in vivo silencing are suggestive of its importance in pregnancy via a role beyond immune tolerance.

Item Type: Article
Uncontrolled Keywords: Hoxa10; autoimmune regulator; bone morphogenetic protein; decidualization; implantation sites; pregnancy
Subjects: Molecular Reproduction
Depositing User: Rgcb Library
Date Deposited: 31 Aug 2017 05:59
Last Modified: 31 Aug 2017 05:59
URI: http://rgcb.sciencecentral.in/id/eprint/441

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