Hima, Sithul and S, Sreeja (2016) Modulatory Role of 17 b -Estradiol in the Tumor Microenvironment of Thyroid Cancer. International Union of Biochemistry and Molecular Biology, 68 (2). pp. 85-96.

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Abstract

Thyroid cancer (TC) is an endocrine related cancer and is well coupled with the female reproductive hormone, 17 b -estradiol (estrogen). Plenty of articles have discussed the role of tumor microenvironment (TME) with different types of tumors in a broad-spectrum but the role of female reproductive hormone, that is, involvement of estrogen in TME of TC have not been reviewed elsewhere. The aim of this review is to analyze how 17 b -estradiol affects the TME of TC and also that subsequently leads to progression of cancer. This review is given a new insight on: 1) the estrogen’s involvement in TME of TC; 2) how it interferes with the complex cross talk of signaling pathways established between cancer cells, host cells, and their sur- rounding extracellular matrix; and 3) the important factors of microenvironment comprising inflammation, hypoxia, angio- genesis, metastasis, various growth factors and fibroblasts in stromal cells. V C 2015 IUBMB Life, 68(2):85–96, 2016

Item Type:	Article
Uncontrolled Keywords:	estrogen; thyroid cancer; tumor microenvironment
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	22 Sep 2017 06:33
Last Modified:	22 Sep 2017 06:33
URI:	http://rgcb.sciencecentral.in/id/eprint/463

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