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Mrunal V, Wanjale and G. S, Vinod Kumar (2017) Peptides as a therapeutic avenue for nanocarrier-aided targeting of glioma. Expert opinion on drug delivery, 14 (6). 811 -824. ISSN 1744-7593

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Abstract

ntroduction: Very few successful interventions have been possible in glioma therapy owing to its aggressive nature as well as its hindrance of targeted therapy together with the limited access afforded by the blood – brain barrier (BBB). With the advent of nanotechnology based delivery vehicles such as micelles, dendrimers, polymer-based nanoparticles and nanogels, the breach of the BBB has been facilitated. However, there remains the issue of targeted therapy for glioma cells. Peptide-mediated surface modification of nanocarriers serves this purpose, extending the ability to target glioma further than the enhanced permeability and retention effect. Areas covered: Here we have tried to re-establish the significance of peptides that could be used in various ways for treating glioma. Peptide-embellished nanocarriers used to deliver anticancer drugs; nucleic acids (siRNA, miRNA); micelles or dendrimers grafted with immunogenic glioma-derived pep- tides used for stimulating active immunity in vaccine therapy, glioma targets for cell penetrating peptides and homing to specific receptors are reviewed. Expert opinion: Peptides have multifunctional potential in targeting, BBB and cell penetration, and can serve as antagonists of various ligands and agonists of particular over-expressed receptors as discussed in this review. Using peptides in targeted personalized therapy would be one step forward and may offer new avenues for glioma therapeutics

Item Type: Article
Uncontrolled Keywords: BBB; Glioma; cell penetrating and homing peptides; nanocarriers for glioma; peptide glioma; peptide vaccines
Subjects: Chemical Biology
Depositing User: Rgcb Library
Date Deposited: 27 Sep 2017 10:39
Last Modified: 27 Sep 2017 10:39
URI: http://rgcb.sciencecentral.in/id/eprint/469

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