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Swathy , B and Moinak, Banerjee (2017) Understanding epigenetics of schizophrenia in the backdrop of its antipsychotic drug therapy. Epigenomics, 9 (5). pp. 721-736. ISSN 1750-192X

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Abstract

The diatheses of gene and environment interaction in schizophrenia (SCZ) are becoming increasingly evident. Genetic and epigenetic backgrounds are being considered in stratifying and addressing phenotypic variation and drug response in SCZ. But how much of these epigenetic alterations are the primary contributing factor, toward disease pathogenesis and drug response, needs further clarity. Evidence indicates that antipsychotic drugs can also alter the epigenetic homeostasis thereby inducing pharmacoepigenomic effects. We re-examine the context of epigenetics in disease pathogenesis and antipsychotic drug therapy in SCZ to understand how much of these observations act as real indicators of the disease or therapeutic response. We propose that epigenetic viewpoint in SCZ needs to be critically examined under the genetic, epigenetic and pharmacoepigenetic background.

Item Type: Article
Uncontrolled Keywords: antipsychotic drugs; epigenetics; histone modifications; methylation; miRNA; pharmacoepigenetics; schizophrenia
Subjects: Human Molecular Genetics
Depositing User: Rgcb Library
Date Deposited: 12 Oct 2017 06:28
Last Modified: 12 Oct 2017 06:28
URI: http://rgcb.sciencecentral.in/id/eprint/477

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