Sankar , Jagadeeshan and Diana, David and Manjula, S. and Jisha, S and S. , Asha Nair (2017) Solanum nigrum Unripe fruit fraction attenuates Adriamycin resistance by down-regulating multi-drug resistance protein (Mdr)-1 through Jak-STAT pathway. BMC Complementary and Alternative Medicine, 17 (370). ISSN 1472-6882

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Abstract

Solanum nigrum, herbal plant that commonly grows in temperate climate zone, has been used as a traditional folk medicine whose ripen fruits were proven to exhibit anti-tumor properties. In traditional Chinese medicine, it has been used for centuries to cure inflammation, edema, mastitis and hepatic cancer and in the Ayurvedic system of traditional medicine in India, S. nigrum is applied against enteric diseases, ulcer, diarrhea and skin diseases. A methanolic glycosidic extract fraction of unripe fruit of S. nigrum (SNME) was investigated for its anticancer property and possible mechanism to surmount adriamycin resistance in NCI/ADR-RES cells.

Item Type:	Article
Uncontrolled Keywords:	Solanum nigrum, Unripe fruits, Methanolic extract, Glycosidic fraction, Cancer, Adriamycin resistance
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	01 Nov 2017 09:19
Last Modified:	01 Nov 2017 09:19
URI:	http://rgcb.sciencecentral.in/id/eprint/490

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