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Mithun Varghese, Vadakkan and G. S., Vinod Kumar (2016) Advancements in Devices and Particle Engineering in Dry Powder Inhalation Technology. Current topics in medicinal chemistry, 16 (18). pp. 1990-2008. ISSN 1873-4294

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Abstract

Dry powder inhalers (DPI) attracted the attention of pharmaceutical field due to its enlarging market share in inhalable formulations. These formulations also pose patient compliance and good shelf life. Earlier DPI formulations were intended for local effect in lung (asthma and chronic obstructive pulmonary diseases), whereas 21(st) century witnessed formulations intended for systemic effect too. A better understanding of physiology of lung and fluidics of air flow helped in targeting alveoli using DPI technology. Modern characterization tools also accelerated the research pace. In addition to the synthetic molecules, DPI also was proved to be a better system for delivering biological molecules including vaccines. This review includes the mechanisms of drug deposition, advancements in the fields of DPI devices, various characterization tools and particle engineering. In this review we have related the chronological advancement of inhalational technology starting from 1788 AD to the present.

Item Type: Article
Uncontrolled Keywords: Inhalation, Particle Engineering, Nanotechnology, DPI, Hypothesis
Subjects: Chemical Biology
Depositing User: Rgcb Library
Date Deposited: 15 Feb 2018 06:35
Last Modified: 15 Feb 2018 06:35
URI: http://rgcb.sciencecentral.in/id/eprint/510

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