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Divya , M.P and Deepa, Mathew and Sabu , Thomas (2015) Mutations in gyrA & parC genes of Shigella flexneri 2a determining the fluoroquinolone resistance. The Indian journal of medical research, 141 (6). pp. 836-8. ISSN 0971-5916

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Shigellosis or bacillary dysentery is caused by a group of facultative anaerobic Gram-negative rods of the genus Shigella. Worldwide, about 165 million cases of shigellosis were reported annually (99% occurring in the developing world) with one million associated deaths1. Approximately 60 per cent of deaths involve children younger than five years2. Four Shigella species, S. dysenteriae, S. flexneri, S. boydii, S. sonnei cause shigellosis in humans. Of these, S. flexneri is the most frequently isolated species in developing countries, which has six serotypes and two variants (X, Y) including subserotypes3-6. Antibiotic therapy lessens the risk of serious complications and death, shortens the duration of symptoms and hastens the elimination of Shigella from the stool. Multidrug resistance is widespread in Shigella and the current treatment of shigellosis is with ciprofloxacin and with three secondline antibiotics; pivmecillinam, azithromycin and ceftriaxone7. Since 2002, there has been an alarming increase in S. flexneri resistant to fluoroquinolones in India, thereby limiting the treatment options8-11. We report here two isolates of S. flexneri type 2a isolated from a hospital in Kerala in 2010 which were found to be resistant to fluoroquinolones and possessed mutations in gyrA and parC genes.

Item Type: Article
Subjects: Environmental Biology
Depositing User: Rgcb Library
Date Deposited: 20 Mar 2018 06:55
Last Modified: 20 Mar 2018 06:55
URI: http://rgcb.sciencecentral.in/id/eprint/531

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