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Divya, Lakshmanan and Leny, Jose and K.P., Suja and Sathish, Mundayoor and R. , Ajay Kumar (2011) Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro. Fitoterapia, 82 (5). pp. 757-761. ISSN 1873-6971

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Many plants are used in Ayurveda for the treatment of tuberculosis. Our aim was to examine if these plants possess any specific molecule that inhibits Mycobacterium tuberculosis. One of them, Kaempferia galanga, yielded an anti-TB molecule, ethyl p-methoxycinnamate (EPMC). By resazurin microtitre assay (REMA), EPMC was shown to inhibit M. tuberculosis H37Ra, H37Rv, drug susceptible and multidrug resistant (MDR) clinical isolates (MIC 0.242-0.485mM). No cross resistance was observed to any standard anti-TB drugs in the MDR strains. The compound did not inhibit any prototype bacteria tested. EPMC seems to be a potential anti-TB lead molecule.

Item Type: Article
Uncontrolled Keywords: Antimycobacterial M. tuberculosis K. galanga Ethyl p-methoxycinnamate REMA
Subjects: Mycobacterium Research
Depositing User: Rgcb Library
Date Deposited: 02 May 2018 10:09
Last Modified: 02 May 2018 10:09
URI: http://rgcb.sciencecentral.in/id/eprint/573

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