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Praveen, Kumar and Anuja , Thulaseedharan and Sabu , Thomas (2011) Characterization of Novel Alleles of Toxin Co-Regulated Pilus A Gene (tcpA) from Environmental Isolates of Vibrio cholerae. Current microbiology, 62 (3). pp. 758-63. ISSN 1432-0991

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Abstract Vibrio cholerae is causative agent of life threatening diarrheal disease, cholera. The toxin co-regulated pilus (TCP) is a critical colonization factor of V. cholerae and it also serves as receptor for CTXФ. In this study, we describe nucleotide sequence of four novel alleles of tcpA gene from toxigenic and non-toxigenic V. cholerae isolated from environmental sources. The phylogenetic analysis of tcpA revealed that it is related to tcpA of newly emerged O1 strain and unrelated to tcpA of wild type (classical and El Tor strains). All strains showed variant tcpA and also harbored intact Vibrio Pathogenicity Island (VPI). The expression of all variant alleles was demonstrated by RT-PCR.

Item Type: Article
Uncontrolled Keywords: Horizontal Gene Transfer Necrotizing Fasciitis Toxigenic Strain Cholerae Strain tcpA Gene
Subjects: Environmental Biology
Depositing User: Rgcb Library
Date Deposited: 03 May 2018 07:15
Last Modified: 03 May 2018 07:15
URI: http://rgcb.sciencecentral.in/id/eprint/577

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