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Vineethkumar, T. V. and Asha, R. and Shyla, G. and Sanil , George (2018) Studies on the Mode of Membrane Interaction of C-terminally Amidated Brevinin1 HYba1 and 2 Peptides Against Bacteria. International Journal of Peptide Research and Therapeutics, 24 (1). pp. 117-129. ISSN 573-3149

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In this study, we investigated the possible mode of action of two C-terminally amidated novel peptides identified from the frog skin on both Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Vibrio cholerae). The results indicate that the peptides initially induce membrane depolarization followed by pore formation in a concentration-dependent manner. A microscopic examination revealed the fact that the peptides are capable of destroying bacterial cells physically. The activity of these peptides against Gram-negative bacteria was dependent on the presence of divalent cations (Ca2+ and Mg2+) but not in Gram-positive bacteria. This study also emphasizes that the endemic frogs of the Western Ghats may provide a valuable source of its skin peptides having the potential for further improvement as lead drug molecules.

Item Type: Article
Uncontrolled Keywords: Amphibian skin peptide Antibacterial activity Brevinin1 Mode of action Western Ghats
Subjects: Molecular Ecology
Chemical Biology
Depositing User: Rgcb Library
Date Deposited: 05 Jun 2018 06:43
Last Modified: 11 Apr 2019 11:15
URI: http://rgcb.sciencecentral.in/id/eprint/601

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