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Aswathy Mary, Simon and Sankar , Jagadeeshan and Emimol , Abraham and Ashalatha , Akhilandeshwaran and Jisha J. , Pillai and Nisha Asok, Kumar and Asha Nair , S and Vinod Kumar, G S (2012) Poly (D,L-lactic-co-glycolide) Nanoparticles for the Improved Therapeutic Efficacy of All-trans-retinoic Acid: A Study of Acute Myeloid Leukemia (AML) Cell Differentiation In Vitro. Medicinal chemistry, 8 (5). pp. 805-10. ISSN 1875-6638

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Abstract

All-trans-retinoic acid reverses malignant cell growth and induces cell differentiation and apoptosis. Poor aqueous solubility and uncertain bioavailability are the limiting factors for using all-trans-retinoic acid for tumor therapy. The objective of present study was to encapsulate the hydrophobic drug all-trans-retinoic acid in the polymer poly (lactide-coglycolide). The encapsulation was expected to improve the bioavailability and solubility of the drug. Oil in water single emulsion solvent evaporation technique used for the preparation efficiently encapsulated about 60% of the drug. The drug release profile showed a biphasic pattern with 70% of the drug being released in first 48 hrs and the residual drug showing a slow controlled release reaching up to 8 days. The particle size of 150-200 nm as determined with TEM was ideal for tumor targeting. All-trans-retinoic acid loaded nanoparticles were efficient to induce differentiation and blocked the proliferation of HL-60 cells invitro. These studies also revealed that the dosage of drug required for the therapeutic effects have been reduced efficiently. Our studies thereby demonstrate that Poly (lactide-co-glycolide) based nanoparticles may be efficient for parenteral administration of the drug.

Item Type: Article
Uncontrolled Keywords: All-trans-retinoic acid, Controlled release, Nanoparticles, cancer, Myeloid leukemia, HL-60.
Subjects: Chemical Biology
Depositing User: Mrs Lathika K
Date Deposited: 08 Jul 2019 10:55
Last Modified: 09 Jul 2019 10:09
URI: http://rgcb.sciencecentral.in/id/eprint/621

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