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Mithun Varghese , Vadakkana and S.S, Binil Rajb and C C, Kartha and G.S., Vinod Kumara (2015) Cationic, amphiphilic dextran nanomicellar clusters as an excipient for dry powder inhaler formulation. Acta biomaterialia, 23. pp. 172-188. ISSN 1878-7568

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Abstract

Effective delivery of drugs to alveoli in a controlled manner using hydrophobic polymers as carriers has already been reported. Preclinical studies revealed that toxicity and hydrophobicity are related to each other in pulmonary delivery. Here, we are reporting a chemically modified dextran having amphiphilicity and cationicity achieved by controlled grafting of stearyl amine. Two proportions of lipopolymers were synthesized and physico-chemical characterization was carried out. In vivo evaluation of sub-acute toxicity of the synthesized lipopolymer in Sprague-Dawley rats was carried out for three months. This was followed by a histological evaluation of the sacrificed animal's lung. Further, the synthesized lipopolymer was formulated with drug (Rifampicin) loaded inhalable microparticles through spray drying. The final drug formulation was tested for toxicity and proinflammatory responses in human cell lines. Dose deposition efficiency of the formulation was determined using Anderson Cascade Impactor.

Item Type: Article
Uncontrolled Keywords: Pulmonary drug delivery; Dextran microparticles; Nanomicelle; Cationic; Amphiphilic
Subjects: Chemical Biology
Depositing User: Rgcb Library
Date Deposited: 27 Dec 2016 02:16
Last Modified: 27 Dec 2016 07:07
URI: http://rgcb.sciencecentral.in/id/eprint/66

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