Satheesh Kumar, Sengodan and Sreelatha, K.H and Revathy, Nadhan and Priya, Srinivas (2018) Regulation of epithelial to mesenchymal transition by BRCA1 in breast cancer. Critical reviews in oncology/hematology, 123. pp. 74-82. ISSN 1879-0461

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Abstract

Reports till its discovery has proven multiple facets of Breast Cancer type 1 susceptibility gene (BRCA1) from nucleus to cytoplasm; from DNA repair to drug resistance; from Homologous Recombination (HR) to Ubiquitination; from breast to brain; from cancer to HIV and many of the roles are still unexplored. One of the recent attractions of BRCA1 is its role in regulating breast cancer metastasis though the exact mechanism is poorly understood. In this review, we will discuss the molecular interactions between BRCA1 and the key molecules of Epithelial to Mesenchymal Transition (EMT) associated with metastasis, its associated drug resistance and the possible treatment strategy for BRCA1 mutated breast cancer.

Item Type:	Article
Uncontrolled Keywords:	BRCA1 epithelial to mesenchymal transition Drug resistance Breast cancer Metastasis
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	30 Jul 2018 08:03
Last Modified:	30 Jul 2018 08:03
URI:	http://rgcb.sciencecentral.in/id/eprint/671

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