Samuthiram , Thalamuthu and Smreti , Vasudevan and Suparna, Sengupta (2013) DNA binding, nuclease, and colon cancer cell inhibitory activity of a Cu(II) complex of a thiazolidine-4-carboxylic acid derivative. Journal of Coordination Chemistry. ISSN 0095-8972

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Abstract

Thiazolidine-4-carboxylic acid derivative (L) derived by condensation of D-penicillamine and 3-methoxy salicylaldehyde was used in synthesis of a copper complex (CuL). The ligand and Cu(II) complex were characterized by elemental analysis and spectral techniques. The DNA binding properties of L and CuL with calf thymus DNA were investigated by various techniques. The ability of compounds to break pUC19 DNA was checked by gel electrophoresis. The radical-scavenging activity was studied using 2,2-diphenyl-1-picrylhydrazyl assay. The ligand and CuL exert cytotoxicity against HCT116 cell line. The compounds were screened for antimicrobial activity against several microorganisms. The effect of the CuL on the surface of penicillium was analyzed by scanning electron microscopy.

Item Type:	Article
Uncontrolled Keywords:	Thiazolidine-4-carboxylic acid derivative; Copper complex; Spectral studies; Biological activity
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	12 Sep 2018 10:42
Last Modified:	12 Sep 2018 10:42
URI:	http://rgcb.sciencecentral.in/id/eprint/684

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