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Remya, Chandran and Mantosh, Kumar and Lakshmi, Kesavan and Reena, SarahJacob and Sowmya, Gunasekaran and Sethu, Lakshmi and Omkumar, R.V (2019) Cellular calcium signaling in the aging brain. Journal of chemical neuroanatomy, 95. pp. 95-114. ISSN 1873-6300

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Abstract

Aging in the biological system is an irreversible process. In the initial stages of lifespan aging improves survival skills of an organism while in the later stages aging reduce the survival skills. Aging is associated with changes in several cellular and molecular functions among which calcium signaling is a prominent one. Calcium signaling is essential for many vital functions of the brain and even minor impairments in calcium signaling can lead to deleterious consequences including neuronal death. Calcium signaling proteins are pursued as promising drug targets for many aging related diseases. This review attempts to summarize changes in calcium signaling in the brain as a result of aging

Item Type: Article
Uncontrolled Keywords: Aging Calcium signaling Neuronal calcium homeostasis Calcium channels Aging associated neurodegenerative disease Oxidative stress Excitotoxicity
Subjects: Molecular Neurobiology
Depositing User: Rgcb Library
Date Deposited: 04 Apr 2019 07:51
Last Modified: 04 Apr 2019 07:52
URI: http://rgcb.sciencecentral.in/id/eprint/719

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