Kumar, R and Li, DQ (2016) PAKs in Human Cancer Progression: From Inception to Cancer Therapeutic to Future Oncobiology. Advances in cancer research, 130. 137-209. ISSN 2162-5557

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Abstract

Since the initial recognition of a mechanistic role of p21-activated kinase 1 (PAK1) in breast cancer invasion, PAK1 has emerged as one of the widely overexpressed or hyperactivated kinases in human cancer at-large, allowing the PAK family to make in-roads in cancer biology, tumorigenesis, and cancer therapeutics. Much of our current understanding of the PAK family in cancer progression relates to a central role of the PAK family in the integration of cancer-promoting signals from cell membrane receptors as well as function as a key nexus-modifier of complex, cytoplasmic signaling network. Another core aspect of PAK signaling that highlights its importance in cancer progression is through PAK's central role in the cross talk with signaling and interacting proteins, as well as PAK's position as a key player in the phosphorylation of effector substrates to engage downstream components that ultimately leads to the development cancerous phenotypes. Here we provide a comprehensive review of the recent advances in PAK cancer research and its downstream substrates in the context of invasion, nuclear signaling and localization, gene expression, and DNA damage response. We discuss how a deeper understanding of PAK1's pathobiology over the years has widened research interest to the PAK family and human cancer, and positioning the PAK family as a promising cancer therapeutic target either alone or in combination with other therapies. With many landmark findings and leaps in the progress of PAK cancer research since the infancy of this field nearly 20 years ago, we also discuss postulated advances in the coming decade as the PAK family continues to shape the future of oncobiology.

Item Type:	Article
Uncontrolled Keywords:	PAK Cancer metastasis Nuclear functions DNA repair Gene expression Breast cancer
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	26 Apr 2019 09:15
Last Modified:	26 Apr 2019 09:15
URI:	http://rgcb.sciencecentral.in/id/eprint/735

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