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Sanalkumar, Rajendran and Indulekha, Chandrasekharan Lalitha and Divya, Thulasi Sheela and Divya, Mundackal Sivaraman and Ruby John , Anto and Vinod, Balachandran and Vidyanand , Sasidharan and Balusamy, Jagatha and Shalini , Venugopal and Jackson , James (2010) ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch-dependent neural progenitors. Journal of neurochemistry, 113 (4). pp. 807-18. ISSN 1471-4159

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Hes-1 and Hes-5 are downstream effectors of Notch signaling that are known to be involved in different aspects of neural stem cell proliferation and differentiation. Evidence has emerged that Hes-1 expression can be regulated by alternate signaling pathways independent of canonical Notch/CBF1 interaction. This context-dependent differential regulation of Hes-1 expression in neural progenitor gains a lot of importance as it would help in its exponential expansion without the requirement of interaction from neighboring cells during development. Here, we have clearly demonstrated the existence of a population of neural progenitors with Notch/CBF1-independent Hes-1 expression in vitro. Further analysis demonstrated the role of FGF2 in activating Hes-1 expression through the direct binding of ATF2, a JNK downstream target, on Hes-1 promoter. This raises the possibility for the existence of two distinct populations of neural progenitors - one maintained by Hes-1 expression exclusively through Notch-independent mechanism and the other mediating Hes-1 expression through both canonical Notch and FGF2-ATF2 pathway. This alternative pathway will insure a constant expression of Hes-1 even in the absence of canonical Notch intracellular domain-mediated signaling, thereby maintaining a pool of proliferating neural progenitors required during development.

Item Type: Article
Subjects: Neuro Stem Cell Biology
Depositing User: Rgcb Library
Date Deposited: 20 May 2019 09:35
Last Modified: 20 May 2019 09:35
URI: http://rgcb.sciencecentral.in/id/eprint/752

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