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Susheelamma, Chithra Janardhanan and Asha Nair, S (2018) Oestrogen, progesterone and stem cells: the discordant trio in endometriosis? Expert reviews in molecular medicine. ISSN 1462-3994

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Oestrogen–progesterone signalling is highly versatile and critical for the maintenance of healthy endometrium in humans. The genomic and nongenomic signalling cascades initiated by these hormones in differentiated cells of endometrium have been the primary focus of research since 1920s. However, last decade of research has shown a significant role of stem cells in the maintenance of a healthy endometrium and the modulatory effects of hormones on these cells. Endometriosis, the growth of endometrium outside the uterus, is very common in infertile patients and the elusiveness in understanding of disease pathology causes hindrance in selection of treatment approaches to enhance fertility. In endometriosis, the stem cells are dysfunctional as it can confer progesterone resistance to their progenies resulting in disharmony of hormonal orchestration of endometrial homeostasis. The bidirectional communication between stem cell signalling pathways and oestrogen–progesterone signalling is found to be disrupted in endometriosis though it is not clear which precedes the other. In this paper, we review the intricate connection between hormones, stem cells and the crosstalks in their signalling cascades in normal endometrium and discuss how this is deregulated in endometriosis. Re-examination of the oestrogen–progesterone dependency of endometrium with a focus on stem cells is imperative to delineate infertility associated with endometriosis and thereby aid in designing better treatment modalities.

Item Type: Article
Uncontrolled Keywords: Endometrial stem cells; oestrogen; progesterone; Wnt; Notch; Hedgehog
Subjects: Cancer Research
Depositing User: Rgcb Library
Date Deposited: 21 May 2019 06:35
Last Modified: 21 May 2019 06:35
URI: http://rgcb.sciencecentral.in/id/eprint/753

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