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Biju, Vasudevanpillai and Sathish , Mundayoor and Omkumar, R V. (2010) Bioconjugated quantum dots for cancer research: Present status, prospects and remaining issues. Biotechnology Advances, 28 (2). pp. 199-213. ISSN 0734-9750

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Semiconductor quantum dots (QDs) are nanoparticles in which charge carriers are three dimensionally confined or quantum confined. The quantum confinement provides size-tunable absorption bands and emission color to QDs. Also, the photoluminescence (PL) of QDs is exceptionally bright and stable, making them potential candidates for biomedical imaging and therapeutic interventions. Although fluorescence imaging and photodynamic therapy (PDT) of cancer have many advantages over imaging using ionizing radiations and chemo and radiation therapies, advancement of PDT is limited due to the poor availability of photostable and NIR fluorophores and photosensitizing (PS) drugs. With the introduction of biocompatible and NIR QDs, fluorescence imaging and PDT of cancer have received new dimensions and drive. In this review, we summarize the prospects of QDs for imaging and PDT of cancer. Specifically, synthesis of visible and NIR QDs, targeting cancer cells with QDs, in vitro and in vivo cancer imaging, multimodality, preparation of QD-PS conjugates and their energy transfer, photosensitized production of reactive oxygen intermediates (ROI), and the prospects and remaining issues in the advancement of QD probes for imaging and PDT of cancer are summarized.

Item Type: Article
Uncontrolled Keywords: Quantum dots Cancer targeting In vitro imaging In vivo imaging Photodynamic therapy Multimodal imaging
Subjects: Cancer Research
Depositing User: Central Library RGCB
Date Deposited: 22 May 2019 07:29
Last Modified: 22 May 2019 07:29
URI: http://rgcb.sciencecentral.in/id/eprint/758

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