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Lekshmi , Narendrakumar and Bhaskar, Das and Balasubramanian , Paramasivan and Jayabalan, Rasu and Sabu, Thomas (2018) Quorum Quenching and Biofilm Inhibition: Alternative Imminent Strategies to Control the Disease Cholera. Biotechnological Applications of Quorum Sensing Inhibitors. pp. 63-85.

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Abstract

Abstract Vibrio cholerae, the causative agent of the disease cholera still threatens a large proportion of world’s population and is considered as a top priority enteric pathogen. Role of biofilm in V. cholerae pathogenesis is well established as it pro-vides the bacterium with enhanced transmission ability during epidemics and also enhanced tolerance to antimicrobial agents. The clinical efficacy of many existing antibiotics is being threatened by the emergence of multi-drug resistant V. cholerae. The rapidly increasing number of cholera outbreaks in several developing countries and emergence of multidrug resistant V. cholerae necessitates the development of an alternative strategy rather than the existing antibiotic therapy to control the patho-gen. In the present chapter, we discuss the different quorum sensing pathways in V. cholerae, the common quorum quenching molecules that targets these pathways and a novel strategy of biofilm inhibition in V. cholerae using antibiofilm com-pounds in combination with antibiotics to control the disease. Co-dosing strategy reduce the dosage of antibiotics and such a combination therapy can in turn be used to control the spread of antibiotic resistance.

Item Type: Article
Uncontrolled Keywords: Antibiofilm compounds Antibiotic resistance Combinatorial therapy Quorum sensing Quorum quenching Vibrio cholerae
Subjects: Cholera And Biofilm
Depositing User: Rgcb Library
Date Deposited: 27 May 2019 11:21
Last Modified: 27 May 2019 11:22
URI: http://rgcb.sciencecentral.in/id/eprint/767

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