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Nimmy, Augustine and Praveen, Kumar and Sabu , Thomas (2010) Inhibition of Vibrio cholerae biofilm by AiiA enzyme produced from Bacillus spp. Archives of microbiology, 192 (12). pp. 1019-1022. ISSN 0302-8933

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Abstract

Vibrio cholerae is the causative agent of water-borne diarrheal disease, cholera. The formation of biofilm favors survival and persistence of V. cholerae in the aquatic environment and also inside the host. AHL lactonase (AiiA), a metallo-beta-lactamase produced by Bacillus spp., blocks quorum sensing in Gram-negative bacteria by hydrolyzing N-acyl-homoserine lactones (AHLs). In the present investigation, AiiA-mediated inhibition of V. cholerae biofilm was studied. Two novel alleles of aiiA-encoding genes from Bacillus spp. were expressed in E. coli, and the results demonstrated that AiiA enzyme is a potent inhibitor of V. cholerae biofilm.

Item Type: Article
Uncontrolled Keywords: AiiA enzyme Biofilm Quorum sensing V. cholerae
Subjects: Cholera And Biofilm
Depositing User: Rgcb Library
Date Deposited: 13 Jun 2019 09:49
Last Modified: 13 Jun 2019 09:49
URI: http://rgcb.sciencecentral.in/id/eprint/784

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