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Reshmi, G. and Sona, Charles and Priyanka, James and Jijith, V.S. and Prathibha, R. and Surya, Ramachandran (2012) OrCa-dB: A complete catalogue of molecular and clinical information in oral carcinogenesis. Oral oncology, 48 (6). ISSN 1879-0593

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Oral Squamous Cell Carcinomas (OSCC), are the most common head and neck neoplasms, that account for about 90% of all oral cancers and is much more common in worldwide especially Asian countries.1 High throughput genomic technologies such as microarray, proteomics, transcriptomics and gene sequencing development has resulted in creation of enormous data and exposure of hundreds of genes and microRNAs that are differentially expressed, thus providing researchers important resources to potentially explore the molecular mechanisms and help in developing diagnostic methods or therapeutic strategies. We believe this integrated knowledge database will serve to provide researchers with a multitude of information related to oral cancer aiming to support researchers as well as clinicians at a molecular level. We have compiled molecular as well as clinical information on oral cancer in a freely accessible database, OrCa-dB, which is available at www.rgcb.res.in/orcadb. OrCa-dB is a compendium of genes, proteins, miRNAs, pathway and tissue specific expression patterns involved in oral cancer development and progression. OrCa-dB was constructed after extensive manual curation of PubMed records, dated from 1970 to December 2011, for genes impaired in molecular and genetic events during oral cancer progression. An important highlight of OrCa-dB is the inclusion of clinically relevant information such as role of socioeconomic background in early diagnosis, benefits of screening interventions, chemotherapeutic drugs, use of targeted therapy, clinical trials in oral cancer, management of patients and their quality of life. Each entry in OrCa-dB is linked to external databases such as UniProt,2 SwissProt,3 KEGG pathway database,4 MirBase,5 EMBL6 and PDB7 as an added advantage for harnessing related biological insights. To the best of our knowledge none of the existing oral cancer databases would cover such a vast expanse of information narrowing down the gap between bench research and clinical evaluation of oral cancer. OrCa-dB will be a specialized, first of its kind value-added database that will enable effortless pursuit of relevant knowledge for all experimentally determined human oral-cancer-related information and their interactomics along with clinical facts, thus making it a unique resource in the area of oral cancer biology. We are working to amplify the quantity of data and to supply additional database function such as querying the database with keywords. Incorporation of additional search and retrieval features to enhance the usability of the web interface will also be considered in the next version of OrCa-dB. Details on microarray and gene expression will also be included in the next update. Since many biological functions involve the formation of protein–protein complexes we also propose to construct a protein interaction map

Item Type: Article
Subjects: Cancer Research
Depositing User: Central Library RGCB
Date Deposited: 10 Jul 2019 05:57
Last Modified: 10 Jul 2019 05:58
URI: http://rgcb.sciencecentral.in/id/eprint/808

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