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Rajendran , Sanalkumar and Dhanesh, S B and Jackson, James (2010) Non-canonical activation of Notch signaling/target genes in vertebrates. Cellular and molecular life sciences, 67 (17). pp. 2957-68. ISSN 1420-9071

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Abstract

Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.

Item Type: Article
Uncontrolled Keywords: Notch signaling CBF1-independent Notch Hes-1 Non-canonical Notch Neural differentiation Tumorigenesis
Subjects: Neuro Stem Cell Biology
Depositing User: Rgcb Library
Date Deposited: 11 Jul 2019 09:35
Last Modified: 11 Jul 2019 09:35
URI: http://rgcb.sciencecentral.in/id/eprint/819

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