Ramshid, P K. and Jagadeeshan, Sankar and Krishnan, Anand and Mathew, Mary and Asha, Nair S and Pillai , M.R (2010) Synthesis and In Vitro Evaluation of Some Isatin-Thiazolidinone Hybrid Analogues as Anti-Proliferative Agents. Medicinal Chemistry, 6 (5). pp. 306-312. ISSN 1573-4064

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Abstract

A range of isatin-thiazolidinone hybrid analogues were synthesized and their cytotoxicity was evaluated against several cancer cell lines in vitro. The acute toxicity studies in mice models revealed that these analogues possess low systemic toxicity and are safe up to 1600mg/Kg. Among the compounds synthesized, 5-(2-nitrobenzylidene)-2-(isatin-3- azino)-thiazolidin-4-one (CI) has been shown to be the most active, highly promising compound which induced S phase arrest in cell cycle in a time dependent manner. Our initial analysis indicate that incorporation of electron withdrawing group at ortho position of the ring favors over the meta and para positions for eliciting its cytostatic effect. Overall, the in vitro biological evaluation suggests that the growth inhibitory effect of CI is promising and can be studied further.

Item Type:	Article
Uncontrolled Keywords:	3-Thiosemicarbazone; 4-Fluorobenzylidene; 4-Hydroxybenzylidene; 5-(2-Nitrobenzylidene); Alzheimer's; Anti-Proliferative Agents; DMEM; DMSO; ELISA microplate reader; Isatin; Isatin-Thiazolidinone Hybrid; NCI ADR Res; Phosphorylation; Trivandrum; anti-prol
Subjects:	Cancer Research
Depositing User:	Central Library RGCB
Date Deposited:	11 Jul 2019 11:12
Last Modified:	11 Jul 2019 11:12
URI:	http://rgcb.sciencecentral.in/id/eprint/821

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